Corticotropin-releasing factor human ( Human CRF; Human corticotropin-releasing factor )

产品货号. M29843 CAS No. 86784-80-7

Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions by reducing hyperpolarizations. Acts as a functional antagonist of inflammatory mediators.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥3269	有现货
10MG	￥5702	有现货
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货

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生物学信息

产品名称

Corticotropin-releasing factor human
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions by reducing hyperpolarizations. Acts as a functional antagonist of inflammatory mediators.
产品描述

Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions by reducing hyperpolarizations. Acts as a functional antagonist of inflammatory mediators.(In Vitro):CRF increases excitability of type II dlBNST neurons through activation of the AC-cAMP-PKA pathway, thereby causing pain-induced aversive responses.(In Vivo):The findings are consistent with a mechanism whereby the excess CRF that characterizes stress-related diseases initiates distinct cellular processes in male and female brains, as a result of sex-biased CRF1 signaling. CRF injection on food intake (FI), CRF suppresses FI in 3-month male and female animals.
体外实验

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体内实验

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同义词

Human CRF; Human corticotropin-releasing factor
通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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化学信息

CAS Number

86784-80-7
分子量

4757.45
分子式

C208H344N60O63S2
纯度

>98% (HPLC)
溶解度

H2O : 16.66 mg/mL (3.50 mM; Need ultrasonic and warming)
SMILES

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化学全称

Sequence:Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

Kaneko T et al. Activation of adenylate cyclase-cyclic AMP-protein kinase A signaling by corticotropin-releasing factorwithin the dorsolateral bed nucleus of the stria terminalis is involved in pain-induced aversion. Eur J Neurosci. 2016 Sep 30.

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